Thin film coating of tablet: pharmaceutical coating process guidelines
Involved in pharmaceutical production, for any pharmaceutical companies, suitable tablet film coating is very important.The technology of advanced technology with the passage of time in the development unceasingly, and varies according to the type of drug formulation.
But why film coating is so important, but drug makers need to know what?This guide will help you understand some of the key factors in the process of film coating, and how to select the most suitable for thin film coating.
What is the film coating of tablet?
Thin film coating is in a tablet or pill surface coating a layer of thin, homogeneous and continuous film.Thin film coating has a variety of purposes, can make the tablet is easy to identify and swallow that control tablet of drug release curve, etc.
Usually, the thin film coating is the most commonly usedCoating tablet type.Thin film coating technology is advanced, complex, and sometimes need to use the calculation model and a variety of coating techniques to achieve the desired results.And in the end, the pharmaceutical companies may use coating type depends on several factors, including the type of drug delivery, expectations and consumer demand.
The purpose of film coating of tablet: coating tablet vs. no coating tablets
Thin film coating of tablet has many advantages, from during manufacture and storage, and ultimately protect the tablet core used by the patients.
The production and storage
A lot of active pharmaceutical ingredient (API) elements such as light, oxidation, water is very sensitive.Thin film coating of tablet can protect the API from the impact of these forces, to ensure that the drugs even after storage for a long time also can continue to play its expected role.
Drug release form
By thin film coating, drug makers can control the release of the API, rate and time.For the need to delay the release of some drugs, or for must be in a specific period of time in terms of drug release constant API is very important.
Patient compliance
Oral tablet is the best way to ensure that patients compliance, because they are the minimal invasive method, at the same time for patients with manufacturers and is also relatively cheaper.Thin film coating tablets more easily, which can improve the patients' compliance.
Enteric coating tablets and thin film coating tablets have to differ?
Slow-release or enteric coating tablets are widely used in the protection of gastric mucosa from stimulating active substances or of gastric juice sensitive drugs.Unlike quick release film coating of tablet, enteric coating tablets will not dissolve in acid, but will dissolve in the small intestine alkaline pH.In other words, the quick release film coating means when swallowing dissolved and release drugs in a short period of time.
Tablet coating process
Usually, use on core surface coating a layer of polymer film coating process in a pill.Tablet coating solution - by specific ingredients such as colorants, made from polymer and plasticizer, and in the form of spray coating to the rotation of the fluidized bed, USES hot air to the solvent (usually water) evaporation from the surface.This will in core surface with a layer of thin film.
Card nu-lax has been constantly innovation, constantly through the coating formulation and process design to improve efficiency.Use of equipment and process may vary with the company and, owing to the different drugs.
The best tablet coating solution
Perfect film coating solution will depend on the nature of the drug and target.Usually there are two main methods to choose from: organic solvent and aqueous film coating solution.
Thin film coating of organic solvents
When the drug is highly sensitive to moisture, usually use organic solvent film coating.The process used in the polymer can well protect the drug from moisture, and reduce drug degradation by hydrolysis.Although for manufacturing is highly sensitive to moisture for drug companies this is a good solution;But using organic solvent are unsafe, and costly.
Aqueous film coating
The aqueous film coating is a very popular and easy application process.Compared with solvent-based coating, the advantages of the aqueous film coating including less environmental pollution, the explosion risk is low, and improved the security of the operating personnel.Aqueous film coating is now the most technologically advanced high performance coating formula, but also on the different types of equipment to expand production scale.
All the formula film coating system for the generation of ® series
The good news is that whether pharmaceutical companies are looking for organic solvent or aqueous film coating solution, they all have a choice: card le kangding formats - step film coating systems:Card nu-lax generation series of Obama,It will be polymer, plasticizer and combined in a dry concentrate the colorant.Generation of film coating Obama in many different types of core is formed on the coating a layer of beautiful and elegant.
If you're looking for thin film coating solution, card nu-lax can provide help for you.We have for the pharmaceutical, nutrition and animal health services the company more than 60 years, our experts are ready to help you for your brand to choose the appropriate thin film coating.Please contact us immediately for consultation, or click hereLearn more about the generation of product information.
