Hydroxypropyl methyl cellulose (HPMC) in the application of slow-release skeleton piece

In the pharmaceutical industry, hydroxypropyl methyl cellulose (HPMC, beauty show ™) can be used as a filler, adhesive, coating polymer and control drug release tablet of key materials.Hydroxypropyl methyl cellulose in the application of pills have more than 60 years of history, is a kind of widely used in the key of the hydrophilic gel matrix tablets accessories.

Many pharmaceutical companies using hydroxypropyl methyl cellulose to control drug release, especially in the hydrophilic gel formula in the skeleton.When it comes to the hydroxypropyl methyl cellulose products, you may want to know how to make a choice, especially if you are looking for some can sell to the customer with friendly and sustainable product label.In this tutorial, we will talk about you need to know about hydroxypropyl methylcellulose key information.

What is the hydroxypropyl methyl cellulose?

Hydroxypropyl methyl cellulose is now known as the hydroxypropyl methyl cellulose (HPMC), is a kind of used as pharmaceutical excipients, can control drug release from oral hydrophilic gel matrix films of polymers.

Hydroxypropyl methyl cellulose is the most abundant polymer in nature - cellulose derived in half a synthetic material.Some of its common properties include:

• Soluble in cold water
• Insoluble in hot water
• nonionic
• Selective soluble in organic solvents
• Reversibility, thermal gel properties
• Hydration and viscosity has nothing to do with pH
• Surface activity
• non-toxic
• Taste and smell
• The enzymatic resistance
• PH (2-13) range stability
• Can be used as thickening agent, emulsifier, binder, speed regulator, film formers

What is a hydrophilic gel skeleton?

Skeleton piece is a kind of hydrophilic gel can be controlled in a long time of drug release from the tablet formulations.

Hydrophilic gel skeleton preparation:

• Relatively simple
• Only need a standard tablet devices
• To prevent drug dose dumping
• Is not affected by tablet hardness or the force that press a piece
• Can be adjusted according to the materials and the polymer injection amount of drug release

Hydroxypropyl methyl cellulose in hydrophilic gel skeleton has gained widely used in the regulatory approval, hydroxypropyl methylcellulose easy to use, good safety record and has been a large number of studies.Hydroxypropyl methyl cellulose has become the pharmaceutical companies to develop and produce the best choice of the slow controlled release tablets.

The influencing factors of skeleton tablet of drug release

When design sustained-release tablets, need to consider two main factors: the formulation and process.In determining the final drug formulation and release curve, there are some factors to consider.

formula

In the early development of the key factors to consider:

1. Polymer (replace type, viscosity, dosage and particle size)
2. Drugs (particle size and solubility)
3. Filler (solubility and dosage)
4. Other accessories gentle granule (stabilizer)

process

These factors related to how the drug production:

1. Mode of production
2. Tablet size and shape
3. The force that press a piece of
4. pH
5. Thin film coating

Skeleton piece of work

Hydrophilic gel skeleton piece by gel layer to control the release of drugs, including diffusion (soluble active ingredient) and dissolution (insoluble active ingredient) two mechanisms, and polymer viscosity has a great influence on release curve.Using hydroxypropyl methyl cellulose, pharmaceutical companies can use hydrophilic gel matrix technology adjust drug release curve, provide more effective drug dosage, better patient compliance, so as to reduce the patients' medical burden.Medicine once a day in the way of course better than several times a day taking multi-disc medication experience.

Slow-release technology

Hydroxypropyl methyl cellulose (beauty show ™) is a well-known and accepted slow-release polymer, besides we have other technology can be fine regulating drug release curve or provide intellectual property rights.

Card nu-lax slow-release technology using a unique combination of polymer coated active drug control release drug at different rates.With the advanced technology, our slow-release products simplifies the development and production of tablets and capsules process, at the same time provide a consistent drug release.

Card nu-lax provide advanced film coating system, such as for slow controlled release preparationsLaurie silkandThe generation of ECAt the same time complementary withOur value-added services,At all stages of product design and development to offer help.

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