Zyban formula: challenges and best practices

For many drugs, simply provide an effective drugs, and then puts it into tablets or capsules, the end, this is not enough.The right dosage and dosing method is important for effective treatment.For magnesium deficiency patients, for example, that a single large doses of this mineral intake does not completely absorbed by the body - and sustained, stable in the diet may be more effective.

This is the slow release effect.Through the slow release, pharmaceutical companies can not only delay the delivery of drugs, can also according to specific parts of the body to release drugs.Is the most common oral preparation time dependence of the release.But the design can achieve the effect of preparation will also face challenges.This guide will be a detailed analysis of some of the challenges, and the best practice is introduced to deal with these challenges.

What is a controlled-release formulation?

Controlled-release formulation is refers to the tablet or capsule is designed in the patients after taking medicine, in the longer term, in the form of controlled release drug.These agents commonly used system includingHydrophilic or hydrophobic skeleton system, storage systems,More granular system, andPermeability release system.

The advantages of slow-release preparation

Many types of drugs slow-release is helpful, there are three key reasons:

1. To improvePatient complianceBecause patients don't have to remember one day how many pills.

2. Ease patients' medical burden", or relieve patients negative psychological effects caused by large amounts of drugs every day.

3. To limit after the initial dose intensity for drugsUndesirable side effectsEven the risk of seizures.

Slow (ER), controlled release (CR) and sustained release (SR)

Controlled release (CR) and sustained release (SR) belong to a broader category of slow-release - also known as adjusting the release.Controlled release refers to drug release for a period of time constant.Sustained release, on the other hand, at a predetermined rate of release of drugs, maintain stable drug concentration in a particular time, minimize side effects.

Slow-release drug is usually oral preparations, but controlled release drug besides oral preparation, can also be other ways to give medicine to the body.

Delayed release (DR) is the release of another form of regulation, theseThe oral solid preparationWidely used in protecting gastric mucosa from stimulating the influence of the active ingredient or drugs to protect sensitive to gastric juice.For example, the medicine to cure the small intestine need before reaching the the parts of the body don't release the active ingredient.These drugs are designed to be a pill or more particles such as oral solid preparation products, including a lot of people are taking proton pump inhibitor (PPI) and enteric aspirin.

The challenge for the zyban formula

When talking about slow release, the pharmaceutical industry is the biggest challenge facing the match the release rate of active pharmaceutical ingredients (API).Tablets after being swallowed, drug formulation must be able to in the right quantity and right time interval of drug release.

Efficient tablet formulation and film coating is vital for successful implementation target release curve, so the pharmaceutical enterprises must choose the right formula, to ensure that drugs can play a role as expected, help patients' adherence to treatment.This will bring better therapeutic effect for patients, so as to improve patients to the credibility of the brand.

Pharmaceutical enterprise effective drug delivery main challenge is to ensure that the release of consistency, and release in the body of the target area.This requires a robust formula and experienced production team reliable and repeatable manufacturing, so that every time can provide a consistent, predictable results.

Zyban formula best practices

In order to ensure the slow-release products can provide consistent and predictable results, the pharmaceutical enterprises should follow some best practices, creating the best products to ensure that:

• To reduce the surface area of the active ingredient.So that we can better control of drug delivery.

• Using the skeleton system.Skeleton including drugs and rate control material mixing and pressing, to slow down the dissolution of the drug.Hydrophilic or hydrophobic polymers are applicable.
  
• Using the modernThin film coating technology.By using different polymer as coating materials, can control the drug dissolution rate, or according to specific parts of the delayed the release.
  
• Using the experienceSupplementary materialSuppliers.A rich formula and manufacturing experience, and high-tech facilities company can help you ensure that the product get the best effect.You need to find a partner company with relevant laboratory facilities, and they have proved to achieve your desired results, at the same time in the skeletal system and thin film coating has a wealth of experience and knowledge.In card nu-lax, we have a specialized technical team, for decades has been deal with and resolve these challenges.Please contact us now.